Journal of Computer Science & Systems Biology

S. Parthasarathy

Publications

• Research Article
  Comparison of the Virulence Factors and Analysis of Hypothetical Sequences of the Strains TIGR4, D39, G54 and R6 of Streptococcus Pneumoniae
  Author(s): R. Jothi, S. Parthasarathy and K. GanesanR. Jothi, S. Parthasarathy and K. Ganesan
  
  Whole genome sequences of the four strains of Streptococcus pneumoniae, encapsulated TIGR4, D39, G54 and nonencapsulated R6 are considered for the comparative study on genome features, whole genome pairwise alignment, gene role category, and virulence factors using relevant comparative genomics tools. The study of capsular polysaccharide synthesizing genes reveals that many cps genes are unique to TIGR4, which shows the high virulence nature of TIGR4. Further, the study on the other virulence factors such as pneumococcal surface protein A, autolysin, hyaluronate lyase, pneumolysin, neuraminidase B, and pneumococcal surface antigen A of TIGR4 are much related to those of the other three strains, and hence the virulence nature due to these factors among four strains seems to be similar. But it differs from neuraminidase A, choline binding protein A and immun.. Read More»
  DOI: 10.4172/jcsb.1000010

  Abstract PDF