Transplantation Technologies & Research

Saami Khalifian

Publications

• Review Article
  The Role of Ischemia-Reperfusion Injury in Reconstructive Transplantation
  Author(s): Saami Khalifian, Damon S Cooney, WP Andrew Lee and Gerald BrandacherSaami Khalifian, Damon S Cooney, WP Andrew Lee and Gerald Brandacher
  
  Reconstructive transplantation, also referred to as vascularized composite allotransplantation (VCA), has rapidly emerged as a viable approach to repairing complex tissue defects. Over the past 20 years, major advances have been made in the field of VCA allowing for successful transplantation of over 150 hand/forearm/arm, larynx, trachea, abdominal wall, vascularized knee, and facial transplants with encouraging outcomes. These innovations have currently outpaced the scientific community’s ability to fully address certain immunological and clinical challenges. The literature on ischemia-reperfusion injury (IRI) in VCA is limited and mechanistic questions remain. Specifically, the role IRI may play in acute rejection, the progression towards chronic rejection, or immune regulation and tolerance induction has only been partially or indirectly addressed. Hence, much of what we unde.. Read More»
  DOI: 10.4172/2161-0991.S3-004

  Abstract PDF