Molecular Biomarkers & Diagnosis

Sagar Sohoni

Publications

• Short Communication
  Elevated Mitochondrial and Heme Function as Hallmarks for Non-Small Cell Lung Cancers
  Author(s): Chantal Vidal, Sagar Sohoni and Li ZhangChantal Vidal, Sagar Sohoni and Li Zhang
  
  Many targeted therapies have been developed to treat lung cancer. Unfortunately, however statistical data over the past two decades suggest only a slight improvement in a patient's survival rate after diagnosis. Clonal evolution and tumor heterogeneity are the major obstacles in designing effective targeted treatments against cancer. To create more comprehensive treatments, emerging therapies target bioenergetic pathways of cancer cells. Like normal cells, cancer cells can generate energy only through glycolysis and oxidative phosphorylation. Notably, a number of studies have shown that many types of cancer cells rely heavily on mitochondrial respiration. Importantly, research carried out in the authors’ laboratory showed that non-small cell lung cancer cells exhibit increased levels of mitochondrial and heme function. Hence, limiting heme availability interferes with bioene.. Read More»
  DOI: 10.4172/2155-9929.1000305

  Abstract PDF