Journal of Cytology & Histology

Said ZS

Publications

• Commentary
  Assessment of Cytogenetic Instability and Gene Transcription of Chronic Myelogenous Leukemia Cells Exposed to Non-thermal Plasma
  Author(s): Elhadary AMA, El-Aragi GM, Ahmed MM and Said ZSElhadary AMA, El-Aragi GM, Ahmed MM and Said ZS
  
  Background: This study investigates the effect of Atmospheric Pressure Plasma Jet (APPJ) on cytogenetic instability and transcription of genes associated with propagation of chronic myelogenous leukemia (CML). Material and methods: Blood samples were collected from six patients with CML and compared with control group. The first three cases were in accelerated phase (AP-CML) resistant to imatinib and nilotinib drugs. The others partially responded and returned to chronic phase (CP-CML). Triple blood cultures for each case were exposed to single dose of plasma, with treatment times of 40, 80, and 120 sec. Mitotic phases, indices and abnormalities, as well transcription levels of P53, caspase-3 and BcL-2 genes were detected before and after plasma jet exposure. Results and conclusion: The data showed that the exposure to.. Read More»
  DOI: 10.4172/2157-7099.1000371

  Abstract PDF