Environmental & Analytical Toxicology

Sameeh A Mansour

Publications

• Research Article
  Impact of Oxidative Stress and Lipid Peroxidation Induced by Lambdacyhalothrin on P450 in Male Rats: The Ameliorating Effect of Zinc
  Author(s): Moustafa A Abbassy, Mamdouh A Marzouk, Sameeh A Mansour, Hassan A Shaldam and Abdel-Tawab H MossaMoustafa A Abbassy, Mamdouh A Marzouk, Sameeh A Mansour, Hassan A Shaldam and Abdel-Tawab H Mossa
  
  The present study was designed to investigate the effect of lambda-cyhalothrin (LCH) on lipid peroxidation, oxidative stress biomarkers and the activity of Cytochrome P450 in male rats and the protective role of zinc. LCH was administrated orally to rats at dose 2.6 mg/kg b.wt. (Which represents 1/10 LD50) with 3 doses per week for 6 weeks (dose period). Rats were divided into four groups, eight rats for, each: (I) control group, (II) zinc group (Zn dose 227 mg/l in drinking water), (III) LCH-treated groups and LCH-Zn group (IV) as in group II and III. The present results demonstrated that LCH induced significant alteration in the activity of antioxidant enzymes (superoxide dismutase, SOD; catalase, CAT; glutathione-s-transferase, GST; glutathione peroxidase, GPx), glutathione reduced (GSH) and lipid peroxidation (LPO) levels and decreased cytochrome P450 (P450) activity in plasma of .. Read More»
  DOI: 10.4172/2161-0525.1000218

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