Molecular Biomarkers & Diagnosis

Samileh Noorbakhsh D

Publications

• Research Article
  Determination the Cut off Level for Synovial S-Tream1 to Differentiate Septic from Aseptic Arthritis: A Cross Sectional Study, Tehran, Iran
  Author(s): Samileh Noorbakhsh D, Mahshid Talebi-Taher, Mohamad Reza Shokrolahi, Vida Zarabi, Azardokht Tabatabaei and Sahar Ghavidel DarestaniSamileh Noorbakhsh D, Mahshid Talebi-Taher, Mohamad Reza Shokrolahi, Vida Zarabi, Azardokht Tabatabaei and Sahar Ghavidel Darestani
  
  Objective: To evaluate the usefulness of STREM-1 level in synovial fluid (SF) to differentiate septic from aseptic arthritis. Methods: A cross sectional study performed in the Pediatrics ward of Rasoul Hospital, Tehran, IRAN (2008- 2009). Out of 66 children, 53 synovial fluid (SF) samples studied. Direct gram stain, conventional and Bactec culture, quantification of STREM-1 level (EIA Quantikine, R&D systems, USA) had done.STREM-1 levels compared between septic (n=26) and aseptic (n=27) arthritis. Chi square values (CI 95%, p<0.05) were considered statistically significant. Results: Septic arthritis diagnosed in 26 cases; S. Aureus (7/18, 38%). SF-STREM-1 Cut off level 825 pg./ml yielded 50% sensitivity, 70% specificity, 64% PPV, 64% NPV. The AUC was 0.603 (95% CI; 0.448-0.757, P = 0.2). SF-STREM-1 Levels were higher in patients with bacterial arthritis in compare with aseptic .. Read More»
  DOI: 10.4172/2155-9929.1000143

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