Molecular Biomarkers & Diagnosis

Samira Shabani

Publications

• Research Article
  Investigation of hTERT Expression Level and its Relation with Clinicopathological Features and Resistance to Chemotherapy in Colorectal Cancer Patients
  Author(s): Samira Shabani, Frouzandeh Mahjoubi, Bahar Mahjoubi and Rezvan MirzaeeSamira Shabani, Frouzandeh Mahjoubi, Bahar Mahjoubi and Rezvan Mirzaee
  
  One of the most common causes of mortality in the world is cancer. In spite of advancement in cancer treatments, the clinical outcome is far away from expectation yet. Drug resistance remains a major obstacle to the effective cure of almost all of the cancers. Telomerase is a ribonucleoprotein enzyme that contains an extremely conserved reverse transcriptase (TERT) component and a template RNA component (TERC or TR). Telomerase activity is infrequently present in normal somatic cells, but it is observed in most cancer cells. This enzyme is actually a key enzyme for human cells to acquire immortality. This study was conducted to investigate possible association between telomerase expression and clinicopathological features as well as the feasible correlation between telomerase expression and clinical response to chemotherapy in Iranian colorectal cancer patients. In this regards tumora.. Read More»
  DOI: 10.4172/2155-9929.1000176

  Abstract PDF