Nuclear Medicine & Radiation Therapy

Samit B. Kadam

Publications

• Research Article
  Cytogenetic Analysis on the Yields of Chromosomal Aberrations Induced by the Scattered Doses of γ-Radiation
  Author(s): Samit B. Kadam, Soorambail K. Shyama, Praveen Kumar MK, Avelyno D’costa and Valentine G. AlmeidaSamit B. Kadam, Soorambail K. Shyama, Praveen Kumar MK, Avelyno D’costa and Valentine G. Almeida
  
  The present study is undertaken to know the radiation dose-response of chromosomes in the non-target cells, viz. peripheral blood lymphocytes of cancer patients in a context of partial body irradiation. The genotoxic effect of γ- radiation was studied in Head and Neck Squamous Cell Carcinoma (HNSCC) patients exposed to various cumulative doses of 60Co gamma rays during radiotherapy (RT). These patients (P1 to P10) were irradiated for a period of six weeks with a daily fraction of 2 Gy, consecutively for 5 days in every week. The clastogenic effects of radiation in these patients were analysed on every weekend employing chromosomal aberration (CA) assay. Radiosensitivity of these patients were analysed by employing linear regression analysis of the CAs induced by irradiation. Genetic damage observed in all patients on a weekly basis were recorded and analysed at the individual le.. Read More»
  DOI: 10.4172/2155-9619.1000270

  Abstract PDF