Medicinal Chemistry

Sandeep Pal

Publications

• Research Article
  From Receptors to Ligands: Fragment-assisted Drug Design for GPCRs Applied to the Discovery of H3 and H4 Receptor Antagonists
  Author(s): Alexander Heifetz, Michael P Mazanetz, Tim James, Sandeep Pal, Richard J Law, Mark Slack and Philip C BigginAlexander Heifetz, Michael P Mazanetz, Tim James, Sandeep Pal, Richard J Law, Mark Slack and Philip C Biggin
  
  G-Protein Coupled Receptors (GPCRs) have enormous physiological and biomedical importance, being the primary target of a large number of modern drugs. The availability of structural information of the binding site of the targeted GPCR plays a key role in rationalization, efficiency and cost-effectiveness of the drug discovery process. However, obtaining structural information on GPCRs using X-ray crystallography or NMR requires a large investment of time and is technically very challenging. This situation significantly limits the ability of these methods to have an impact in drug discovery for GPCR targets in the short term and hence there is an urgent need for other effective and cost-efficient alternatives. We present here a practical approach that integrates GPCR modelling with fragment based screening to provide structural insights on the H3 and H4 histamine recep.. Read More»
  DOI: 10.4172/2161-0444.1000158

  Abstract PDF