Medical Microbiology & Diagnosis

Sandra Marilia de Souza Silva

Publications

• Research Article
  Tissue Changes in Experimental Cryptococcosis in Immunocompetent and Immunodeficient Murine Model
  Author(s): Eriques Gonçalves Silva, Josemar Neves Cavalcanti, Flavio Cesar Viani, Sandra Marilia de Souza Silva and Amanda Latercia Tranches DiasEriques Gonçalves Silva, Josemar Neves Cavalcanti, Flavio Cesar Viani, Sandra Marilia de Souza Silva and Amanda Latercia Tranches Dias
  
  Cryptococcosis is a subacute or chronic disease caused through the inhalation of infectious particles from the opportunistic yeast Cryptococcus neoformans spp. The objective of the present study was to evaluate cryptococcosis in a murine model Immunocompetent (BALB/c), as well as in a model with combined immunodeficiency (SCID) through histopathological analyzes of pulmonary and cerebral tissues. After intravenous inoculation with 3.0 × 105 viable yeast cells the animals were euthanized daily for evaluation. The study period was 15 days. There were no significant changes in lung tissue in immunocompetent murine model (BALB/c). While in brain tissue, it was observed: congested vessel, evolving when C. neoformans was visualized in the meningeal area, and a large area of ischemia, which evolved throughout the studied period culminating on the 15th day of inoculation with visualizat.. Read More»
  DOI: 10.4172/2161-0703.1000271

  Abstract PDF