Journal of AIDS & Clinical Research

Sandro Mancinelli

Publications

• Research Article
  Antiretroviral Treatment-Associated Hepatotoxicity and Anemia in Patients Receiving Stavudine or Zidovudine Containing Regimens in Sub- Saharan African Settings
  Author(s): Dieter Wenderlein, Paola Scarcella, Ines Zimba, Richard Luhanga, Sandro Mancinelli, Maria Cristina Marazzi, Ersilia Buonomo, Stefano Orlando, Leonardo Palombi and Giuseppe LiottaDieter Wenderlein, Paola Scarcella, Ines Zimba, Richard Luhanga, Sandro Mancinelli, Maria Cristina Marazzi, Ersilia Buonomo, Stefano Orlando, Leonardo Palombi and Giuseppe Liotta
  
  Objective: Purpose of this study was to assess the prevalence and risk factors associated with development of hepatotoxicity and anemia following initiation of antiretroviral treatment (ART) containing stavudine (d4T) or zidovudine (AZT) in the first year of treatment in the African setting. Method: We evaluated aspartate aminotransferase and haemoglobin levels at baseline and at 1, 2, 3, 6, 9 and 12 months following ART initiation among 10,537 HIV-1 infected, ART-naïve, non-pregnant adults in Mozambique and Malawi. The Cox proportional hazards model was used to assess risk factors for hepatotoxicity and anaemia in the first year following ART initiation. Results: The prevalence of ART-associated hepatotoxicity grades 1-2 declined in the first 3 months of ART from 13.5% to 10.8%, and grades 3-4 from 2.0% to 0.2% from month 1 t.. Read More»
  DOI: 10.4172/2155-6113.1000537

  Abstract PDF