Journal of AIDS & Clinical Research

Santasabuj Das

Publications

• Research Article
  Antimicrobial Peptides in Cervicovaginal Lavage of Women Married to HIV Sero-Reactive Men are not Associated with Resistance to HIV but Modulate Mucosal Pro-Inflammatory Response
  Author(s): Asim Biswas, Atri Ta, Aritra Das, Samiran Panda and Santasabuj DasAsim Biswas, Atri Ta, Aritra Das, Samiran Panda and Santasabuj Das
  
  Objectives: It is critical to understand the HIV transmission dynamics in women, who are married to HIV seropositive men and either go into HIV concordant relationship (WCR) or remain HIV discordant (WDR) over a period of time. Antimicrobial peptides (AMPs) are known to possess anti-HIV activities and may offer protection against acquisition of HIV. We investigated if AMP expression is associated with HIV sero-negative status of the WDR population, and how the co-regulated innate immune responses at the genital mucosa differ between WDR and WCR individuals in eastern-India. Methods: Levels of human beta-defensins, human neutrophil peptides 1-3 and IL-8 were measured by ELISA in the cervicovaginal lavarge (CVL) collected from WCR and WDR individuals. Moreover, we studied the activation of TLR signalling pathways and TNF-alpha induction in THP-1 cells by the m.. Read More»
  DOI: 10.4172/2155-6113.1000444

  Abstract PDF