Journal of AIDS & Clinical Research

Sara Saad

Publications

• Commentary
  A New Controversial Pathophysiology Confirms that HIV does not Kill the CD4+ T-Cell But Mutates Its Physiological Behavior Becoming an Unaccountable CD8+ T-Cell
  Author(s): Salah Sh, Ghaleb HA, Sara Saad and Nada SherifSalah Sh, Ghaleb HA, Sara Saad and Nada Sherif
  
  HIV pathogenesis is known to cause a progressive depilation of CD4+ T-cell cell population in close association with progressive impairment of cellular immunity and increase the susceptibility to infection. This new study is giving a new explanation about the mode of action of this virus. We assume that there is an alteration in the physiological behavior of CD4+ T-cells causing it to mutate to CD8+ T-cells and that CD4+ T-cell are neither destroyed nor lost during the infection. Twelve consenting adults took part in a randomized control trail, six were tested positive for HIV and had never received any antiretroviral therapy while the other six were tested negative. Blood samples withdrawn from participants were tested for total CD4+ T-cells and CD8+ T-cells .Infected cells from HIV positive patients were stimulated with a purified recombinant HIV-1 p17 matrix as a viral protein alon.. Read More»
  DOI: 10.4172/2155-6113.1000640

  Abstract PDF