Journal of Clinical & Medical Genomics

Sarolta Bacsa

Publications

• Review Article
  NRP1 Activates NF-κB Signaling Pathway and Initiates Proliferation in Keratinocytes
  Author(s): Nikoletta Nagy, Katalin Farkas, Sarolta Bacsa, Istvan Balazs Nemeth, Zsuzsanna Bata-Csorgo, Lajos Kemeny and Marta SzellNikoletta Nagy, Katalin Farkas, Sarolta Bacsa, Istvan Balazs Nemeth, Zsuzsanna Bata-Csorgo, Lajos Kemeny and Marta Szell
  
  Background: Neuropilin-1 (NRP1) is a membrane-bound co-receptor of vascular endothelial growth factor receptors (VEGFRs) and type-A plexins. These complexes mediate the effects of ligands such as vascular endothelial growth factor 165 (VEGF165) and semaphorin 3A (SEMA-3A). Aim: Our aims were to elucidate whether the expression of NRP1 is related to the proliferation or differentiation programme of keratinocytes and to identify putative downstream signaling pathways of NRP1 in keratinocytes. Materials and methods: Synchronized HaCaT cells and paraffin-embedded tissue samples of psoriasis were used to modell highly proliferative stages of keratinocytes. Real-time RT-PCR-based expression array was used to analyse downstream signaling pathways in keratinocytes. Results: Synchronized HaCa.. Read More»
  DOI: 10.4172/2332-0672.1000102

  Abstract PDF