Cancer Science & Therapy

Sarrazin Stéphane

Publications

• Research Article
  Endocan as a Biomarker of Endothelial Dysfunction in Cancer
  Author(s): Sarrazin Stéphane, Maurage Claude-Alain, Delmas Dominique, Lassalle Philippe and Delehedde MaryseSarrazin Stéphane, Maurage Claude-Alain, Delmas Dominique, Lassalle Philippe and Delehedde Maryse
  
  Endocan also called endothelial cell-specific-molecule-1 is a product of endothelial cells, highly regulated by vascular endothelial growth factor and expressed during the switch between dormant to fast-growing angiogenic tumors. No other molecule is currently known to be a read out of endothelial activation and dysfunction in tumor progression. We here reviewed the present knowledge about endocan that present clinical value as a tissue- and blood- based prognostic and potentially as a companion biomarker in cancer. By immunohistochemistry endocan was shown to be overexpressed into endothelial cells of small and large vessels in lung, kidney and brain tumors. High endocan serum levels were shown to be significantly correlated with the presence of metastasis and with limited survival in kidney and lung cancers. Moreover, endocan release by endothelial cells was in vitro modulated by ad.. Read More»
  

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