Medicinal Chemistry

Satish John

Publications

• Research Article
  Synthesis, Characterization, Identification and Quantification of Sertraline Hydrochloride Related Impurities
  Author(s): Ajit Anerao, Vihar Telange, Nitin Bondre, Satish John, Vikram Dighe, Rajendra Jagushte and Nitin PradhanAjit Anerao, Vihar Telange, Nitin Bondre, Satish John, Vikram Dighe, Rajendra Jagushte and Nitin Pradhan
  
  Sertraline hydrochloride is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class, is synthesized for commercial use as a drug substance in highly pure form. During the synthetic process development studies of Sertraline hydrochloride, an impurity was detected in the final product at levels ranging from 0.05% to 0.15% in Gas Chromatography (GC) method and its molecular weight was determined by LC-MS analysis. The impurity was identified as 4-(4-chlorophenyl)-3,4-dihydronaphthalen-1(2H)-ol impurity, synthesized and characterized, the process of its formation was discussed in detail. After qualification of impurity standard, it was used as a reference standard for development of quantification by High Performance Liquid Chromatography (HPLC) method. .. Read More»
  DOI: 10.4172/2161-0444.1000414

  Abstract PDF