Journal of Bioanalysis & Biomedicine

Satish Kumar Garg

Publications

• Research Article
  Comparative Disposition Kinetics of Meloxicam Following a Single Intravenous Bolus Dose and Its Concurrent Administration with Ofloxacin in Yak and Cattle
  Author(s): Fakar Uddin Ali Ahmed, Rajkumar Singh Yadav and Satish Kumar GargFakar Uddin Ali Ahmed, Rajkumar Singh Yadav and Satish Kumar Garg
  
  Present study describes the comparative pharmacokinetic (PK) profile of meloxicam (0.5 mg.kg-1) alone its concurrent administration with ofloxacin (7.5 mg.kg-1) by intravenous route in yak and cattle. Plasma concentration of meloxicam was determined by HPLC assay and pharmacokinetic parameters by compartmental method using “PHARMKIT” software. Following intravenous administration of meloxicam alone, t1/2α, t1/2β, AUC, Vdarea and ClB values were found to be 0.21+0.04 h, 4.65+0.40 h, 25.46+1.22 μg/ml.h, 1.97+0.11 L/kg and 0.35+0.02 L/h/kg, respectively in yak and all these values were almost comparable to those found in cattle. But the values of K12/K21, Vc, Vp and fc differed significantly between yak and cattle. Further, no significant differences were observed in values of majority of the pharmacokinetic parameters between meloxicam alone or its concurrent a.. Read More»
  DOI: 10.4172/1948-593X.1000144

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