Cancer Science & Therapy

Saurabh S Bundela

Publications

• Review Article
  Ellagic Acid – Chemopreventive Role in Oral Cancer
  Author(s): Prakash S Bisen, Saurabh S Bundela and Anjana SharmaPrakash S Bisen, Saurabh S Bundela and Anjana Sharma
  
  Ellagic acid is an antioxidant and an anti-proliferative compound present in fruits, nuts and vegetables. In spite of evidences for anticancer activity in various cancer cell-lines, human cancer cells, the mechanistic role of ellagic acid is not conclusive enough to be recommended for a clinical use. The present review provides information about the chemopreventive role of ellagic acid in oral cancer and proposes molecular basis for ellagic acid’s inhibitory activity against oral cancer. We show that ellagic acid modulates growth of tumor cells through regulation of multiple cell signaling pathways including cell proliferation pathway (cyclin dependent kinase 2, cyclin A2, cyclin B1, cyclin D1, c-myc, PKCα), cell survival/apoptosis pathway (Bcl-XL, Bax, Caspase 9/3, Akt), tumor suppressor pathway (p53, p21), inflaming Metastasis pathways (IL-1 beta, TNF-α, matrix metal.. Read More»
  DOI: 10.4172/1948-5956.1000106

  Abstract PDF