Cardiovascular Diseases & Diagnosis

Saverio Bellusci

Publications

• Research Article
  FGF10 Signaling Enhances Epicardial Cell Expansion during Neonatal Mouse Heart Repair
  Author(s): Nicole Rubin, Ali Darehzereshki, Saverio Bellusci, Vesa Kaartinen and Ching Ling LienNicole Rubin, Ali Darehzereshki, Saverio Bellusci, Vesa Kaartinen and Ching Ling Lien
  
  Unlike zebrafish and newt hearts, mammalian hearts have limited capacity to regenerate. Upon injury or disease, the adult mammalian hearts form a fibrotic scar. Recently, it was shown that neonatal mouse hearts can regenerate similarly to adult zebrafish hearts. However, this capacity quickly decreases after postnatal day 7 (P7). Understanding the molecular mechanisms underlying neonatal heart regeneration might lead to therapeutic approaches for regenerating adult mammalian hearts. In this study, we utilized an inducible transgenic mouse model to determine the effects of FGF10 growth factor over expression on neonatal mouse heart regeneration/repair. Over expression of FGF10 in myocardium enhanced the expansion of Wt1 positive epicardial cells at 21 days after heart injury through increased proliferation. However, this expansion of epicardial cells did not lead to increased epithelia.. Read More»
  DOI: 10.4172/2329-9517.1000101

  Abstract PDF