Neurological Disorders

Sawarkar Vaibhav

Publications

• Review Article
  Conotoxins: Possible Therapeutic Measure for Huntingtons Disease
  Author(s): Pallavi Bhosle and Sawarkar VaibhavPallavi Bhosle and Sawarkar Vaibhav
  
  Huntington’s disease (HD) is a genetic disorder with autosomal dominant inheritance with progressive degeneration of neurons. It is characterized by affective, cognitive, behavioral, and motor dysfunctions. 3 nitropropionic acid is well established animal model which initiates a complex series of neurochemical and signaling changes that lead to pathological events including neuronal excitotoxicity by excessive glutamate release, neuroinflammation and energy impairment. Excitotoxins like NMDA and kainic acid which binds to these receptors to release high levels of glutamate that can cause excitotoxicity by allowing high levels of calcium ions (Ca2+) to enter the cell. Ca2+ influx into cells activates a number of enzymes, including phospholipases, endonucleases, and proteases such as calpain. These enzymes increase apoptosis, oxidative stress and energy impairment thereby causing .. Read More»
  DOI: 10.4172/2329-6895.1000129

  Abstract PDF