Journal of Cytology & Histology

Seham Abd El-Aleem

Publications

• Research Article
  Co-upregulation of Transforming Growth Factor Beta-1 and Nitric Oxide Synthase in Keloid by comparison to normal human skin-A possible role for TGF�Ž�²1 and NOS in pathogenesis of keloid
  Author(s): Seham Abd El-Aleem, Soha Abdelwahab and Noura Mohamed Saber OsmanSeham Abd El-Aleem, Soha Abdelwahab and Noura Mohamed Saber Osman
  
  Keloid disease is a benign but progressive form of abnormal wound healing associated with skin fibrosis and can cause a major functional disability and morbidity. TGF beta (TGFβ) and Nitric Oxide (NO) are active biomarkers known to regulate phases of wound healing and have been implicated in pathogenesis of fibrotic disease. There are three isoforms of TGFβ (1, 2 and 3), TGFβ1 and 3 have a crucial role in fibrosis, with TGFβ1 profibrotic and TGFβ3 antifibrotic. NO is produced by Nitric Oxide Synthase (NOS) which exist in three isoforms, inducible NOS (iNOS), endothelial NOS (ecNOS) and neuronal NOS (nNOS). TGFβ isoforms and NO were found to be associated with fibrotic disorders affecting the skin. We hypothesis that the interaction between TGFβ and NO in keloid could promote the excessive collagen deposition associated with this disorder. Using immun.. Read More»
  DOI: 10.4172/2157-7099.1000474

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