Journal of Cytology & Histology

Seham Abd El-Raouf Abd El-Aleem

Publications

• Research Article
  Inhibition of Wound TGF Beta-1 by Celecoxib: A Possible Therapeutic Route for Scar Free Wound
  Author(s): Seham Abd El-Raouf Abd El-Aleem and Edward JudeSeham Abd El-Raouf Abd El-Aleem and Edward Jude
  
  Background: Wound healing is a highly ordered dynamic process associated with inflammation at early stages and with permanent scarring at late stages. Scars could be disfiguring and could advance to be hypertrophic or keloid scars, this would have a strong physical and psychological impact on the patients afterward. The role of inflammatory mediators which could be pro- or anti-inflammatory, pro-or antifibrotic was the focus of wound healing research for decades and the balance between them is the key factor determining the outcome of healing. Aims: In this study, we investigate the correlation and the interrelation between the pro-inflammatory Cyclooxygenase-2 (COX-2) and the pro fibrotic (TGF-Beta-1) in an in vivo model of incisional dermal wound healing and the effect of a selective COX-2 inhibiton the progression of repair and scar formatio.. Read More»
  DOI: 10.4172/2157-7099.1000481

  Abstract PDF