Medicinal Chemistry

Selamu Kebamo

Publications

• Research Article
  Evaluation of Diuretic Activity of Different Solvent Fractions of Methanol Extract of Carissa edulis Root Bark in Rats
  Author(s): Selamu Kebamo, Eyasu Makonnen, Asfaw Debella and Bekesho GeletSelamu Kebamo, Eyasu Makonnen, Asfaw Debella and Bekesho Gelet
  
  Background: Carissa edulis is used traditionally for the treatment of HIV/AIDS symptoms, rheumatism, gonorrhea, syphilis, rabies, malaria, epilepsy, chronic joint pain, and as a diuretic. Objective: The present study investigates the diuretic activity of different solvent fractions of 80% methanol Soxhlet extract of Carissa edulis root bark in normal wistar rats. Materials and methods: The volumes of urine output and urinary electrolyte were the parameters determined by oral administration of single doses of different solvent fractions of 80% methanol Soxhlet extract of Carissa edulis root bark at three dose levels (50, 500 and 1000 mg/kg) in normal wistar rats. Results: The petroleum ether and n-butanol fractions showed no significant effect on the urine.. Read More»
  DOI: 10.4172/2161-0444.1000304

  Abstract PDF