Journal of Bioanalysis & Biomedicine

Sergio Papa

Publications

• Review Article
  Alternative Splicing and Nonsense Mediated Decay in Mitochondrial Complex-I Biogenesis and its Implication in Human Diseases
  Author(s): Damiano Panelli, Francesca Paola Lorusso, Francesco Papa, Anna Maria Sardanelli and Sergio PapaDamiano Panelli, Francesca Paola Lorusso, Francesco Papa, Anna Maria Sardanelli and Sergio Papa
  
  In mammals, complex-I (NADH-ubiquinone oxidoreductase) of the mitochondrial respiratory chain has 31 supernumerary subunits in addition to the 14 conserved from prokaryotes to humans. Multiplicity of structural protein components, as well as of biogenesis factors, make complex-I a sensible pace-maker of mitochondrial respiration. The work reviewed here shows that the Alternative Splicing and Nonsense Mediated Decay pathways regulate the transcription products of different nuclear genes encoding subunits of complex I. Complex-I dysfunction has been found to be associated with several human diseases. Involvement of altered pattern of transcription products of complex-I genes in pathogenetic mechanisms of these diseases is examined... Read More»
  DOI: 10.4172/1948-593X.S3-006

  Abstract PDF