Journal of Bioanalysis & Biomedicine

Settimio Grimaldi

Publications

• Commentary
  Magnetically Driven Bioreactors as new Tools in Drug Delivery
  Author(s): Monia Taranta, Ilaria Naldi, Settimio Grimaldi, Laura Salvini, Pier Paolo Claudio, Francesca Rocchio, Alex F. Munoz, Stefano Prete and Caterina CintiMonia Taranta, Ilaria Naldi, Settimio Grimaldi, Laura Salvini, Pier Paolo Claudio, Francesca Rocchio, Alex F. Munoz, Stefano Prete and Caterina Cinti
  
  The pharmacological properties of many drugs can be improved by drug delivery systems able to drive therapeutic agents to target regions. The use of carriers, in fact, may reduce possible cytotoxic effects of drugs and increase their bioavailability at the site of action, thus improving the efficacy and the safety of treatments. Therefore, we have developed an erythrocyte-based drug delivery system (erythro-magneto-HA virosome), which has the potential to be magnetically guided to specific sites and to fuse with target cells. These engineered erythrocytes have demonstrated in previous work a very high in vitro capability to release anticancer drugs directly inside target cells. Because the erythro-magneto-HA virosomes (EMHVs) proved to be promising carriers, we decided to investigate in more details the effectiveness and safety of this erythrocyte-based drug delivery system... Read More»
  DOI: 10.4172/1948-593X.S5-002

  Abstract PDF