Journal of AIDS & Clinical Research

Seyed Mehdi Sadat

Publications

• Review Article
  How can Improve DNA Vaccine Modalities as a Therapeutic Approach against HIV Infections?
  Author(s): Nourieh Habibzadeh, Azam Bolhassani, Rouhollah Vahabpour and Seyed Mehdi SadatNourieh Habibzadeh, Azam Bolhassani, Rouhollah Vahabpour and Seyed Mehdi Sadat
  
  The recent studies have focused on the improvement of effective prophylactic and therapeutic approaches to combat persistent viral infections. Several therapeutic vaccine strategies have already used such as live-attenuated microbes, viral vectors and dendritic cell-based vaccines led to suppress and/or clear infections. Among them, improved DNA vaccines have emerged as a promising candidate for treatment of infectious diseases especially HIV infections. These vaccines have the advantages of safety, low cost of production, ease of use due to their stability in room temperature as well as ability to elicit efficient immune responses. Some strategies have been considered to improve immune responses stimulated by DNA vaccines, e.g., genetic optimization of plasmid DNA constructs encoding antigens, in vivo efficient DNA delivery systems, co-delivery with molecular adjuvan.. Read More»
  DOI: 10.4172/2155-6113.1000440

  Abstract PDF