Cancer Science & Therapy

Sgambato A

Publications

• Research Article
  Expression of CD133 Correlates with Tumor Stage, Lymph Node Metastasis and Recurrence in Oral Squamous Cell Carcinoma
  Author(s): Reggiani Bonetti L, Migaldi M, Boninsegna A, Fanali C, Farina M, Chiarini L, Anesi A, Cittadini A, Leocata P, Maccio L and Sgambato AReggiani Bonetti L, Migaldi M, Boninsegna A, Fanali C, Farina M, Chiarini L, Anesi A, Cittadini A, Leocata P, Maccio L and Sgambato A
  
  Objective: CD133 is a pentaspan membrane protein expressed by the so-called cancer stem cells (CSC) in the majority of human cancers. The aim of this study was to analyze CD133 expression levels in specimens of oral cancer and to evaluate its relation with disease evolution. Methods: Expression of the CD133 protein was evaluated by immunostaining in a series of oral squamous cell carcinoma (OSCC) and its relation with traditional prognostic indicators and the clinical outcome of patients was analyzed. Results: CD133 expression was highly variable amongst different samples with a median percentage of positive cells of 5 (range 0 - 80; mean = 11) and CD133 staining was not detectable in tumor cells in 29 (43%) cases. No correlation was observed with age at diagnosis, gender and grading while .. Read More»
  DOI: 10.4172/1948-5956.1000255

  Abstract PDF