College of Dentistry,
Erbil
Research Article
The Effect of Green Tea Extract on Submandibular Salivary Gland of Methotrexate Treated Albino Rats: Immunohistochemical Study
Author(s): Ali Sultan Al- Refai, Ameera Kamal Khaleel and Shaheen AliAli Sultan Al- Refai, Ameera Kamal Khaleel and Shaheen Ali
Background and objectives: Methotrexate (MTX) had been used for many years and complications usually encountered during treatment especially in cancer patients. The aim of the present study was to determine the preventive and early-stage anti cytotoxic effects of green tea on the histology of the submandibular gland of rats treated by high single dose of methotrexate.
Materials and methods: The study included 36 Albino rats. Twelve animals were used in the pilot study to find the maximum toxic dose, and the other twenty four were divided into four groups, vehicle treated control group, green tea extract treated control group (40 mg/kg/day), methotrexate treated group (80 mg/kg), and methotrexate and green tea extract treated group. Submandibular glands excisions were then performed. Histopathological examination was performed with hematoxylin-.. Read More»
DOI:
10.4172/2157-7099.1000212
Journal of Cytology & Histology received 2476 citations as per Google Scholar report