Molecular Biomarkers & Diagnosis

Shaimaa M. Hassan

Publications

• Research Article
  Contribution of PON1 Polymorphism in Senile Cataract among Diabetic and Non-Diabetic Egyptian Patients
  Author(s): Ola M. Ali, Laila Kamal Effat, Khalda Sayed Amr, Amira A. Abdel Azeem and Shaimaa M. HassanOla M. Ali, Laila Kamal Effat, Khalda Sayed Amr, Amira A. Abdel Azeem and Shaimaa M. Hassan
  
  Background: The development of senile cataract is a multifactorial process with oxidative stress and its sequelae are clearly involved in its etiology. Cataract is also one of the earliest secondary complications of diabetes mellitus. Paraoxonase (PON) enzyme is an antioxidant High-Density Lipoprotein (HDL)-associated enzyme. In mammals, three genes of paraoxonase, PON1, PON2, and PON3, have been identified. Aim: To assess the contribution of PON1-55 and PON1-192 gene polymorphisms as risk factors for senile cataract formation among diabeticand non-diabetic Egyptian patients. Methods: 132 Egyptian cataract patients (66 without diabetes and 66 with diabetes) and 106 subjects with matched age and sex free of cataract and diabetes control subjects were included in the present study using multiplex PCR for PON1-55 and .. Read More»
  DOI: 10.4172/2155-9929.1000180

  Abstract PDF