Medicinal Chemistry

Shamsuzzaman

Publications

• Review Article
  Strategies for the Synthesis of Thiazolidinone Heterocycles
  Author(s): Ashraf Mashrai, Ayaz Mahmood Dar, Shafia Mir and ShamsuzzamanAshraf Mashrai, Ayaz Mahmood Dar, Shafia Mir and Shamsuzzaman
  
  Thiazolidinones is the special class of heterocyclic compounds with a broad spectrum of biological activities such as anti-inflammatory, antiproliferative, antihistaminic, anti-HIV, hypnotic, anaesthetic, antifungal, anthelmintic and antiviral agents as well as CNS stimulants. Therefore researchers have synthesized these condensed heterocycles through different complex pathways as target structures for biological studies. This review focuses on the various strategies followed for the convenient synthesis of thiazolidinone based heterocyclic derivatives. The steps included condensation followed by cyclization of Schiff’s bases, either in a step-wise manner or in one pot under different conditions. Mercaptoacetic acid, thiolactic acid, chloroacetyl chloride, potassium thiocyanate, ethylchloro acetate and ammonium thiocyanate are t.. Read More»
  DOI: 10.4172/2161-0444.1000358

  Abstract PDF