Medicinal Chemistry

Shankar Jayarama

Publications

• Research Article
  Angio Suppressive Effect of Clitoria ternatea Flower Extract is Mediated by HIF-1α and Down Regulation of VEGF in Murine Carcinoma Model
  Author(s): Kaythegowdanadoddi Srinivasa Balaji, Priyanka Shivaprakash, Saligrama Devegowda Preethi, Kagepura Thammaiah Chandrashekara, Lokesh Siddalingaiah, Kanchugarakoppal Subbegowda Rangappa and Shankar JayaramaKaythegowdanadoddi Srinivasa Balaji, Priyanka Shivaprakash, Saligrama Devegowda Preethi, Kagepura Thammaiah Chandrashekara, Lokesh Siddalingaiah, Kanchugarakoppal Subbegowda Rangappa and Shankar Jayarama
  
  Angiogenesis is a vital process in the progression of cancer as it also play a key role in tumor transition from its dormant state to a malignant stage. VEGF is key growth factor plays an important role in angiogenesis and is regulated by transcription factor HIF-1α. Natural compounds derived from plants have been a prime source for numerous clinically useful anti-cancer agents specially for targeting neo-angiogenesis. Medicinal plants continue to play a central role in the healthcare system of large proportions of the world’s population, particularly true in developing countries like India. In the current report, we studied the angio suppressive effect of aqueous extract of Clitoria ternatea in EAC cells induced angiogenesis. In vivo anti-angiogenic effect of C. ternatea was demonstrated by the down regul.. Read More»
  DOI: 10.4172/2161-0444.1000392

  Abstract PDF