India
Research Article
Vitamin D Receptor Genetic Variants among CKD Patients of South Indian Population
Author(s): Selvaraman Nagamani, Shanmuga Perumal M, Ankit Srivastava, kh. Dhanachandra Singh, Ritushree Kukreti and Karthikeyan MuthusamySelvaraman Nagamani, Shanmuga Perumal M, Ankit Srivastava, kh. Dhanachandra Singh, Ritushree Kukreti and Karthikeyan Muthusamy
Background and Objectives: Vitamin D Receptor (VDR) gene polymorphism has long been known for its association with Chronic Kidney Disease (CKD). We aimed to investigate the potential role of VDR gene polymorphisms in CKD patients. Design and Methods: The association of VDR gene polymorphisms in CKD patients (N=147; males =100 (68.03%) and females=47 (31.97%)) is investigated in this study. The patient samples were compared with healthy control subjects (N=210; males: 130 (61.90%) and females: 80 38.10%)). Genotyping was carried out by polymerase chain reaction–restriction fragment length polymorphism method (PCR_RFLP). All the tatistical analysis was carried out using the SPSS and PLINK-software. Results: A significant difference in the genotype frequency of ApaI-“CC.. Read More»
DOI:
10.4172/2472-128X.1000152
Journal of Clinical & Medical Genomics received 391 citations as per Google Scholar report