Molecular and Genetic Medicine

Shanmugam R

Publications

• Research Article
  The Prevalance of Sensori-Neural Hearing Loss and Ototoxicity in Acute Myeloid Leukemia Patients
  Author(s): Shanmugam R, Raman R, Zakaria MZ and Chang KMShanmugam R, Raman R, Zakaria MZ and Chang KM
  
  Objective: The aim of this study is to investigate the prevalence of sensori-neural hearing loss and ototoxicity in acute myeloid leukemia (AML) patients. Study design: This is a prospective non-randomized study. Methods: 14 patients with the diagnosis of acute myeloid leukemia were treated with Daunorubicin and Cytarabine (ARA-C). Pure Tone Audiometry (PTA) was performed prior to induction chemotherapy and immediately after completion of induction protocol. Primary outcome was the prevalence of sensori-neural hearing loss. Secondary outcome was correlation of age, sex, absolute neutrophil counts, total white counts, platelet counts and creatinine levels in the study population. Results: Fourteen patients participated in this study (n=14). Ten patients had normal hearing prior to preinduc.. Read More»
  DOI: 10.4172/1747-0862.1000280

  Abstract PDF