Journal of Spine

Shanquan Sun

Publications

• Research Article
  Protective Effect of Electro-Acupuncture on Neural Myelin Sheaths Mediated through Activation of Epidermal Growth Factor Receptor after Compressed Spinal Cord Injury
  Author(s): Rui Gong, Shanquan Sun, Qi Zhao, Yuan Zhong, Haijun Yu, Lan Ma, Shiye Xu, Wei Zhang, Kejie Mou and Jun XueRui Gong, Shanquan Sun, Qi Zhao, Yuan Zhong, Haijun Yu, Lan Ma, Shiye Xu, Wei Zhang, Kejie Mou and Jun Xue
  
  Electro acupuncture has been widely used to treat demyelinating diseases, such as multiple sclerosis (MS), acute haemorrhagic leukoencephalitis (AHLE), compressed spinal cord injury (CSCI). However, the protective effect of electro acupuncture (EA) on neural myelin sheaths remains controversy attributed to the dimness of its therapeutic mechanism. In this study, we tried to explore the protective mechanism of EA in a custom-designed model of CSCI. Zusanli (ST36) and Huantiao (GB30) acupoints were stimulated by EA. The motor functions were monitored by Basso, Beattie and Bresnahanloco motor rating scale. The pathological changes in axonal myelinated fibers were estimated by luxol fast blue (LFB) and transmission electron microscopy (TEM). Epidermal growth factor receptor (EGFR), oligodendrocyte transcription factor 2 (Olig2), caspase-3 and phosphorylated Akt1 (pAkt1) were detected by i.. Read More»
  DOI: 10.4172/2165-7939.1000332

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