Molecular and Genetic Medicine

Sharma R

Publications

• Mini Review
  New Delhi Metallo Beta Lactamase: Menace and its Challenges
  Author(s): Kashyap A, Rani Gupta, Sharma R, Verma VV, Gupta S and Pradeep GoyalKashyap A, Rani Gupta, Sharma R, Verma VV, Gupta S and Pradeep Goyal
  
  Clinicians have been facing an enormous challenge of treating infections caused by multiple drug resistant (MDR) pathogens since long. The latest and most alarming of such challenge is the emergence of New Delhi Metallo-β-Lactamase-type 1 (NDM-1) producing clinical isolates. NDM-1 is a metallo β-lactamase that confers resistance to all β-lactam antibiotics including carbapenems generally regarded as last resort to treat infections. NDM-1 is part of a huge conjugative plasmid blaNDM capable of rapid dissemination via horizontal gene transfer, transposition and recombination. Therefore, it has become a matter of global concern now as these pathogens have surpassed all geographical barriers and are threatening the public health all over the world. In addition to this, NDM-1 gene coexists with other resistance determinants such as other M.. Read More»
  DOI: 10.4172/1747-0862.1000299

  Abstract PDF