Metabolomics:Open Access

Sharon Li Ting Pek

Publications

• Research Article
  miR-22 and miR-23a Control Glycerol-Dependent Gluconeogenesis by Regulating Aquaporin 9 Expression
  Author(s): Dwi Setyowati Karolina, Arunmozhiarasi Armugam, Sugunavathi Sepramaniam, Sharon Li Ting Pek, Michael TK Wong, Su Chi Lim, Chee Fung Sum, Subramaniam Tavintharan and Kandiah JeyaseelanDwi Setyowati Karolina, Arunmozhiarasi Armugam, Sugunavathi Sepramaniam, Sharon Li Ting Pek, Michael TK Wong, Su Chi Lim, Chee Fung Sum, Subramaniam Tavintharan and Kandiah Jeyaseelan
  
  In obese individuals, a high efflux of glycerol from accumulated fat in adipose tissue into the liver is known to be associated with the development of type 2 diabetes. Aquaporin 9 (AQP9) is an aquaglyceroporin which serves as the primary route of hepatic glycerol uptake for gluconeogenesis. Hence, development of AQP9 blockers/regulators may be of potential benefit in controlling hyperglycaemia especially in obese and diabetic individuals. HTS13286 was recently identified as a specific AQP9 inhibitor, even so its limited solubility renders the molecule unsuitable for in vivo application. microRNAs are naturally occurring gene regulators that are often associated with various diseases. The feasibili.. Read More»
  DOI: 10.4172/2153-0769.S2-002

  Abstract PDF