Neurological Disorders

Shimizu S

Publications

• Short Communication
  A Cyclooxygenase 2 Gene Polymorphism is a Risk Factor for the Complication of Medication Overuse Headaches in Patients with Migraines
  Author(s): Ishii M, Katoh H, Kurihara T, Saguchi KI, Miyasaka Y, Shimizu S and Kawamura MIshii M, Katoh H, Kurihara T, Saguchi KI, Miyasaka Y, Shimizu S and Kawamura M
  
  We determined whether cyclooxygenase-2 (COX-2) gene polymorphisms were involved in the aggravation of migraines due to the overuse of medication. Polymorphisms in the COX-2 (rs20417, rs689466) gene were examined. Forty-seven patients with migraine (6 males and 41 females; 5 with migraines with aura (MA), 36 with migraines without aura (MO), 6 with MA + MO; 1 with MA and 21 with MO; 36.4 ± 10.3 years) and 22 patients with medication overuse headache (MOH) (1 male and 21 females; 39.6 ± 9.9 years) who had migraines participated in this study. The genotypes of each polymorphism were analyzed by polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) methods. No significant differences were observed in the genotypic distributions of rs20417 (C/C + G/C vs. G/G, p=0.220) between migraine patients and MOH patients. The frequencies of the rs689466 G/G gen.. Read More»
  DOI: 10.4172/2329-6895.1000206

  Abstract PDF