Journal of Cytology & Histology

Shinichi Murata

Publications

• Research Article
  Microscopic Invasion Patterns and Epithelial Cell-phenotypes in Early Gastric Cancer with Submucosal Invasion
  Author(s): Kazuhiro Fukatsu, Jun Kato, Toru Niwa, Mikitaka Iguchi, Yousuke Muraki, Takao Maekita, Izumi Inoue, Izumi Inoue, Hideyuki Tamai, Hisanobu Deguchi, Kosaku Moribata, Yoshimasa Maeda, Yasushi Nakamura, Shinichi Murata and Masao IchinoseKazuhiro Fukatsu, Jun Kato, Toru Niwa, Mikitaka Iguchi, Yousuke Muraki, Takao Maekita, Izumi Inoue, Izumi Inoue, Hideyuki Tamai, Hisanobu Deguchi, Kosaku Moribata, Yoshimasa Maeda, Yasushi Nakamura, Shinichi Murata and Masao Ichinose
  
  Background and study aims: Early gastric cancers show gastric and/or intestinal phenotypes with specific mucin production profiles, and the phenotypes can vary with tumor progression. The aim of this study was to evaluate the correlation between tumor invasion patterns and phenotypes in the mucosa and submucosa of early gastric cancers. Methods: Phenotypic expressions of 44 endoscopically resected gastric cancers with submucosal invasion were evaluated immunohistochemically using MUC5AC and MUC6 as gastric and MUC2 and CD10 as intestinal phenotypic markers. Results: Cancers were classified into two patterns by invasion pattern: 19 collapsing pattern (C-pattern) tumors had cancer cells that invaded to the submucosa with expansive destruction of the muscularis mucosae, while 25 passing-through pattern (P-pattern) tumors .. Read More»
  DOI: 10.4172/2157-7099.1000380

  Abstract PDF