Pharmaceutical Regulatory Affairs: Open Access

Shintani H

Publications

• Research Article
  Serum or Saliva Extraction of Toxic Compounds from Methyl Methacrylate Dental Materials and HPLC Analysis Combined with SPE
  Author(s): Shintani HShintani H
  
  Methyl methacrylate polymer (PolyMMA) is widely used as the composite resin for the dental plate. During the  preparation process of PolyMMA by the polymerization reaction, benzoylperoxide (BPO) and N,N’-dimethylp-toluidine(DMPT) are added as the initiator and the stimulator, respectively. These compounds exhibit toxicity as well as a residue potential, their use raises concerns regarding human safety. The degree of elution into serum or saliva was determined to evaluate risk to the user. Analysis was by HPLC combined with solid-phase extraction using a C-18 column. The eluted compounds were found .. Read More»
  DOI: 10.4172/2167-7689.1000123

  Abstract PDF