Neurological Disorders

Shizheng Wu

Publications

• Review Article
  Preventing and Reversing “Microglia-Aging” by Nature Materials for Slow Brain-Aging. J Neurol Disord 2:143.
  Author(s): Zhou Wu, Aiqin Zhu, Shizheng Wu and Hiroshi NakanishiZhou Wu, Aiqin Zhu, Shizheng Wu and Hiroshi Nakanishi
  
    Abstract Mitochondrial DNA (mtDNA), which encodes components of the mitochondria electron transfer complexes, is highly susceptible to damage produced by reactive oxygen species (ROS), due to its close proximity to ROS generated through the respiratory chain and the paucity of protective histones. Accumulation of mtDNA damages during aging result in the reduced expression of the mitochondria electron transfer complexes, especially complex I. The resultant reduced activity of complex I further increases the generation of ROS, forming a vicious cycle. During aging, the accumulation of oxidative mtDNA damages is prominently found in the brain resident microglia. Increased intracellular ROS, in turn, drives microglia to provoke excessive neuroinflammation in the aged brain through activation of nuclear factor-κB (NF- κB). Hypoxia activates microglia to induce .. Read More»
  DOI: 10.4172/2329-6895.1000143

  Abstract PDF