Journal of AIDS & Clinical Research

Shobha Swaminathan

Publications

• Short Communication
  Evaluation of FIB-4 Index as a Marker for Hepatocellular Carcinoma in HIV -Hepatitis C Co-Infection
  Author(s): Sobia Nizami, Jason Zucker and Shobha SwaminathanSobia Nizami, Jason Zucker and Shobha Swaminathan
  
  Background: Chronic co-infection with hepatitis C (HCV) and HIV leads to progressive liver fibrosis and increases the risk for hepatocellular carcinoma (HCC), creating the need for cancer surveillance. However, screening methods for HCC are controversial. We evaluated Fibrosis-4 (FIB-4); an index calculated from platelet count, alanine aminotransferase, aspartate aminotransferase and age; as a screening tool for HCC in patients with HIV-HCV coinfection. Methods: This was a retrospective chart review of adult outpatients followed at our HIV clinic for the period 2008- 2014, including 11 patients with HIV-HCV co-infection and HCC. Age- and sex-matched control groups were selected, including patients with co-infection without cirrhosis or HCC, HIV mono-infection; and patients with co-infection and cirrhosis without HCC. Mean FIB-4 indices were calculated for ea.. Read More»
  DOI: 10.4172/2155-6113.1000570

  Abstract PDF