Medicinal Chemistry

Shu Yuasa

Publications

• Research Article
  Lentinan, A Shiitake Mushroom �Ž�²-Glucan, Stimulates Tumor-Specific Adaptive Immunity through PD-L1 Down-Regulation in Gastric Cancer Cells
  Author(s): Hiroko Ina, Masahiko Yoneda, Mitsuro Kanda, Yashiro Kodera, Megumi Kabeya, Shu Yuasa, Takae Kataoka, Ryuichi Furuta and Kenji InaHiroko Ina, Masahiko Yoneda, Mitsuro Kanda, Yashiro Kodera, Megumi Kabeya, Shu Yuasa, Takae Kataoka, Ryuichi Furuta and Kenji Ina
  
  Background: Despite the significant advances in chemotherapy, the prognosis of unresectable gastric cancer is still very poor and the role of immunotherapy remains to be clarified. We examined whether lentinan, a biological response modifier, could enhance the chemotherapeutic effects. Materials and methods: A retrospective cohort study was conducted to evaluate the survival benefits of lentinan among the patients with gastric cancer receiving chemotherapy. To investigate the mechanisms underlying the clinical effects of lentinan, its cytotoxic activity was accessed by cell proliferation assay. The expression of molecules relevant to immune checkpoints were analyzed by real-time PCR using human gastric cancer cell lines; MKN1, MKN45, and NUGC3. Results: The addition of lentinan prolonged the survival of patients wi.. Read More»
  DOI: 10.4172/2161-0444.1000419

  Abstract PDF