Nuclear Medicine & Radiation Therapy

Shyama Prem S

Publications

• Research Article
  Early Cardiac Changes Due to Doxorubicin Based Chemotherapy and Radiotherapy in Early and Locally Advanced Carcinoma Breast Patients: An Observational Study
  Author(s): Vinin NV, Shyama Prem S, Ajithananathakrishna Pillai, Reddy KS, Dhanapathi Halanaik and Sudhakar KotlapatiVinin NV, Shyama Prem S, Ajithananathakrishna Pillai, Reddy KS, Dhanapathi Halanaik and Sudhakar Kotlapati
  
  Objective: To evaluate prospectively the early cardiac changes from doxorubicin based chemotherapy and radiotherapy in breast cancer patients. Methods and Materials: 56 patients with early or locally advanced breast cancer were included in the study. ECG, ECHO and Equilibrium Radionuclide Ventriculography (ERV) was done at baseline, after chemotherapy, after radiotherapy and at 6 months of follow up. Results: In Group 1 patients who completed six cycles of chemotherapy before starting radiation, the mean LVEF decreased after chemotherapy and after RT(from 66.79 ± 3.73 to 63.45 ± 3.54 and 61.64 ± 4.26, p<0.05). In Group 2 patients who received six cycles of chemotherapy after completion of radiotherapy, mean LVEF decreased post RT and post chemotherapy (from 66.67 ± 4.33 to 66 ± 4.975 and 62.7 ± 2.92, p<0.05).In Group 3 pa.. Read More»
  DOI: 10.4172/2155-9619.S7-004

  Abstract PDF