Cancer Science & Therapy

Siddik Sarkar

Publications

• Research Article
  Azurin Synthesis from Pseudomonas Aeruginosa MTCC 2453, Properties, Induction of Reactive Oxygen Species, and p53 Stimulated Apoptosis in Breast Carcinoma Cells
  Author(s): Sankar Ramachandran, Siddik Sarkar, Abhijit Mazumadar and Mahitosh MandalSankar Ramachandran, Siddik Sarkar, Abhijit Mazumadar and Mahitosh Mandal
  
  Breast cancers are usually treated with surgery and radiation excretes adverse effects. Azurin, a potent anticancer redox protein secreted by Pseudomonas aeruginosa (P. aeruginosa) species has been reported to have activity against breast cancer cell lines; this had prompted researchers to search for novel methods to enhance this protein's production. Researchers previously have reported on the synthesis of blue copper protein azurin from different microbial sources specifically from P. aeruginosa. Our investigation used customized methods to focus on synthesizing azurin from different strains of P. aeruginosa with apparent homogeneity. We screened the growth of different P. aeruginosa strains (1934, 741, 2453, and 1942) for the synthesis of azurin and for enhanced azurin production. We exposed azurin properties using matrix-assisted laser desorption/ionization, sodium dodecyl sulfate.. Read More»
  DOI: 10.4172/1948-5956.1000069

  Abstract PDF