Biosensors & Bioelectronics

Silva Pereira MC

Publications

• Research Article
  Flow Cytometry Analysis of Pro- and Anti-inflammatory Cytokines in Alzheimer's Disease Model Treated with Ginkgo biloba
  Author(s): Salgado ASI, Eltchechem CL, Ivo Ilvan Kerppers, Silva Pereira MC, Suckow PT, Gomes JC, Hosni AP, Miri AL and Carraro ESalgado ASI, Eltchechem CL, Ivo Ilvan Kerppers, Silva Pereira MC, Suckow PT, Gomes JC, Hosni AP, Miri AL and Carraro E
  
  Alzheimer's disease (AD) is a neurodegenerative disorder that accounts for two-thirds of dementia cases in the elderly and may show preliminary symptoms for decades. The dry leaf extract of Ginkgo biloba (EGb 761) has been used as a dietary supplement for the treatment of mental disorders in both humans and animals. Objective: This study examined the immunological effect of EGb 761 in the treatment of rats with experimental Alzheimer's disease. Methodology: The sample consisted of 40 Wistar male rats, weighing 200-250 grams and divided into 4 groups: 21 days control, 42 days control, 21 days treated, and 42 days treated. Stereotaxic surgery was performed with the coordinates of AP=-3.12, ML=3.6 mm, and DV=3.0; animals were undisturbed for 5 days after surgery and brought back to stereotaxic to be injected with 2 μL (1 mg) of Beta-amiloide25-35 toxin in the CA1 region. Animals in .. Read More»
  DOI: 10.4172/2155-6210.1000241

  Abstract PDF