Journal of AIDS & Clinical Research

Silvana Duarte Pessoa

Publications

• Research Article
  Long-Term Persistence of Hepatitis A Antibodies in Pediatric HIV-Infected Patients after Primary Immunization: Association with Immunological Profile and Response to Revaccination
  Author(s): Aida de Fátima Thomé Barbosa Gouvêa, Maria Isabel de Moraes-Pinto, Maristela Miyamoto, Silvana Duarte Pessoa, Daisy Maria Machado and Regina Célia de Menezes SucciAida de Fátima Thomé Barbosa Gouvêa, Maria Isabel de Moraes-Pinto, Maristela Miyamoto, Silvana Duarte Pessoa, Daisy Maria Machado and Regina Célia de Menezes Succi
  
  Background: We analyzed the persistence of hepatitis A virus (HAV) antibodies 7 years after primary immunization in pediatric HIV-positive patients and its association with the immunological profile. Methods: 29 vertically HIV-infected adolescents (median age, 12.9 years) were enrolled. All of them had been HAV-vaccinated with two HAV vaccine doses 7 years before and all had seroconverted. HAV antibodies were measured by electrochemiluminescence. Lymphocyte immunophenotyping was performed by flow cytometry. Adolescents who lost HAV antibodies were revaccinated. Results: 23/29 patients (79.3%) persisted HAV seropositive (HAV antibodies≥20mlU/mL) 7 years after primary immunization. Age, gender, clinical progression of HIV infection, median viral load, and antiretroviral therapy were similar between those who persisted HAV seropositive and those who lost seropositivity.. Read More»
  DOI: 10.4172/2155-6113.1000295

  Abstract PDF