Veterinary Science & Technology

Simon Platt R

Publications

• Research Article
  Clinical, Imaging and Pathological Characteristics of Brain Implanted Polylactic Co-Glycolic Acid Polymers Conjugated with Temozolomide
  Author(s): Jill Hicks, Simon Platt R, Shannon Holmes P, Elizabeth Howerth, Allison Haley, Jared Kaplan M and Edward Kaplan JJill Hicks, Simon Platt R, Shannon Holmes P, Elizabeth Howerth, Allison Haley, Jared Kaplan M and Edward Kaplan J
  
  Definitive treatments for primary brain tumours are still sought. Slow-release local chemotherapy may provide a good effect and poly (lactide-co-glycolide) (PLGA) microcylinders could allow this. We evaluated the neurological and histopathological consequences, and MRI visibility, of PLGA microcylinders conjugated with temozolomide and gadolinium implanted in normal canine brains. Eight purpose-bred beagles had cerebral implantation of microcylinders combined with temozolomide and gadolinium. MRI was performed following implantation and 28d later prior to necropsy and brain histopathology. All adverse events were associated with implantation and resolved. Dogs with six microcylinders at 0 and 6.25% gadolinium had mild inflammation and all other dogs had greater brain inflammation, which increased with higher gadolinium concentrations and microcylinder number. Microcylinders with gadol.. Read More»
  DOI: 10.4172/2157-7579.1000325

  Abstract PDF