Journal of Computer Science & Systems Biology

Sivaramakrishnan S

Publications

• Research Article
  Systems Biotechnology: an Energing Trend in Metabolic Engineering of Industrial Microorganisms
  Author(s): Chellapandi P, Sivaramakrishnan S and Viswanathan M.BChellapandi P, Sivaramakrishnan S and Viswanathan M.B
  
  The improvement of production processes to achieve commercially viable production levels is a prerequisite to any bioprocess. Currently, production strains are enhanced using a combination of random and targeted approach. By combining metabolomics technology and genome data analysis, it is possible to replace empirical target-selection strategies with a more scienti fi c approach. All steps of biotechnological development, from up-stream and mid-stream to down-stream processes will bene fi t signi fi cantly by taking systems biotechnological approaches. The prevalence of genome sequence information, in concert with modern molecular biology advances, should have facilitated the easy manipulation of speci fi c genes and pathways for the production of microbial metabolites. A notable success has been .. Read More»
  DOI: 10.4172/jcsb.1000054

  Abstract PDF