Cancer Science & Therapy

SM Hadi

Publications

• Review Article
  DNA Reactive Activities of Some Endogenous Metabolites and their Putative Role in the Induction of Cancer
  Author(s): Nida Rehmani and SM HadiNida Rehmani and SM Hadi
  
  One of the most intriguing scientific mysteries is the origin of cancer. DNA damage plays a potent role in mutagenesis, carcinogenesis and ageing. There has been growing realization in recent years that endogenous substrates or metabolites may be an important source of damage caused to cellular DNA. Further, evidence indicates that endogenous DNA damage occurs at a high frequency as compared to exogenous damage. Such findings have debunked the notion that the genetic material is pristine in the absence of exogenous carcinogens. An in-depth knowledge of the types of endogenous DNA damage is essential for understanding the influence of damage caused by endogenous substrates on the induction of cancer. Therefore, in this review, we have focused on several classes of endogenous metabolites and their putative role in mutagenesis and carcinogenesis from a structural, biological and analytic.. Read More»
  DOI: 10.4172/1948-5956.1000364

  Abstract PDF