Medicinal Chemistry

Sobia Ahsan Halim

Publications

• Research Article
  Attempt to Explore the Binding Mechanism of IL-1β Inhibitors via Molecular Docking Studies
  Author(s): Sobia Ahsan Halim and Muhammad JawadSobia Ahsan Halim and Muhammad Jawad
  
  IL-1β is an important cytokineinvolved in several immune responses. IL-1β exerts its effect by binding with its receptorcalled IL-1R1 and leading to a series of intra-cellular signalling. The over-expression of IL-1β leads to immunological complications including arthritis and auto-immune disorders. Currently there are several drugs in the market to cure the inflammation either by inhibiting the production of IL-1β or affecting its signal cascade. The hindrance in the interaction between IL-1β interaction and its receptor can stop its function hence hope to cure inflammatory diseases. This study presents a docking analysis of five commercially available drugs at the IL-1β/IL-1R1 protein interface. This study would give an insight for designing the drugs, capable to block the direct interaction of IL-1&bet.. Read More»
  DOI: 10.4172/2161-0444.1000300

  Abstract PDF